Hou et al (2005) researched the autonomic results of modafinil in humans. They observed that modafinil affects the locus coeruleus, which mediates pupil diameter and arousal, but it doesn't have an affect on other autonomic capabilities, that happen to be managed by noreadrenergic Regulate centers (A1 – A5) located outside of the locus coeruleus.

carbamazepine will minimize the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

En gruppe legemidler som motvirker depresjon ved å øke konsentrasjonen av signalstoffene noradrenalin og serotonin i hjernen.

mitotane decreases levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Mitotane is a powerful inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for achievable dosage changes.

You have to Examine to make certain that it can be Protected so that you can get modafinil with your entire medicines and health issues. Don't start out, end, or change the dose of any drug without examining using your doctor.

modafinil will improve the degree or impact of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Citalopram 20 mg/day is the maximum advisable dose for people getting CYP2C19 inhibitors due to hazard of QT prolongation.

Limits of Use In OSA, modafinil tablets are indicated to take care of excessive sleepiness instead of as cure for the underlying obstruction. If constant optimistic airway strain (CPAP) may be the procedure of option for a individual, a maximal effort to deal with with CPAP for an ample period of time needs to be made ahead of initiating And through remedy with modafinil tablets for too much sleepiness. 2 DOSAGE AND ADMINISTRATION

Not encouraged in sufferers with angina, cardiac ischemia, and recent heritage of myocardial infarction, still left ventricular hypertrophy or mitral valve prolapse

modafinil will enhance the stage or result of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindicated. Potent or average CYP2C19 inhibitors here may well raise mavacamten systemic exposure, leading to heart failure as a result of systolic dysfunction.

modafinil will reduce the extent or outcome of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Solid or average CYP3A4 inducers might improve amount of diazepam elimination; as a result, efficacy of diazepam might be reduced.

Legemiddelgruppe som hemmer enzymet hydroksymetylglutarylkoenzym A (HMG-CoA) i leveren og i andre vev. HMG-CoA er et enzym i tidlig fase av kolesterolsyntesen. Enzymet katalyserer og er hastighetsbegrensende i dannelse av forstadier til kolesterol og en rekke andre biologisk viktige substanser.

It is also occasionally known as multiorgan hypersensitivity. It is a reaction that can impact multiple elements of the body, together with your liver, kidneys, and heart. Quit using modafinil and have assist at once Should you have any of the subsequent signs of a serious allergic reaction.

istradefylline will raise the degree or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

modafinil will raise the stage or influence of diazepam intranasal by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Strong or reasonable CYP2C19 inhibitors could lower amount of diazepam elimination, thus expanding adverse reactions to diazepam.